what is lyrica?

Drug class lyrica

Antiepileptic
GABA analogue
Finished preparations

Lyrica ® also Pregabalin

Effect

Lyrica is an anticonvulsant, analgesic and anxiolytic-acting gamma-aminobutyric acid analogue. It binds to voltage-dependent calcium channels, so that the channels closed, thus reducing the calcium influx at the nerve endings and the release of excitatory neurotransmitters such as glutamate, noradrenaline and substance P is decreased.

Mechanism of action

Pegabalin is a gamma-aminobutyric acid analogue with the chemical name (S) -3 - (aminomethyl)-5-methylhexanoic. It binds to a subunit of auxilia (alpha2-delta protein) of spannungsabhängigien calcium channels in the CNS and potently displaced [3H]-gabapentin. By binding the channels are closed, thus reducing the calcium influx at the nerve endings and decreases the release of excitatory neurotransmitters such as glutamate, substance P and norepinephrine. lyrica does not bind to GABA receptors and therefore has no GABAergic activity.

Contraindications (counter indications)

The following are absolute counter indications (situations in which the drug should be administered in any case) and relative contraindications (situations in which the drug should be administered with caution) listed. For more information or answers to your questions please use the forum or ask your doctor or pharmacist.

Absolute contraindications
- Hypersensitivity to lyrica
- Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption

Relative contraindications
- Severe heart failure
- Pregnancy
- Breast-feeding



Side effects (adverse reactions)



This is a complete list of the known side effects, for more information or answers to your questions please use the forum or ask your doctor or pharmacist.

Adverse effects, without specifying the frequency
- Was Suicidal ideation and suicidal behavior in patients treated with antiepileptic agents in several indications. The mechanism for this risk is not known and the available data do not exclude the possibility of an increased risk when taking Lyrica.
- The observed under one-Thrapie lyrica side effects with the underlying disease and / or concomitant medications related.
- According to market the following side effects have been reported:
- Hypersensitivity, angioedema, allergic reaction
- Aggression
- Loss of consciousness, mental impairment, headache, malaise
- Loss of vision, keratitis
- Heart failure, QT prolongation
- Pulmonary edema
- Swollen tongue, diarrhea, nausea
- Stevens-Johnson syndrome, pruritus
- Urinary retention
- Facial

Very common adverse reactions (> 1 / 10)
Dizziness, drowsiness

Common adverse reactions (> 1 / 100)
increased appetite, euphoria, confusion, irritability, decreased libido, disorientation, insomnia, ataxia, incoordination, memory impairment, attention deficit disorders, tremor, dysarthria, paraesthesia, sedation, vertigo, lethargy, blurred vision, diplopia, vertigo, vomiting, dry mouth, constipation, flatulence , erectile dysfunction, peripheral edema, feeling drunk, edema, abnormal gait, fatigue, weight gain

Uncommon adverse reactions (> 1 / 1000)
Nasopharyngitis, anorexia, hypoglycemia, depersonalization, anorgasmia, restlessness, depression, agitation, mood swings, depression, difficulty finding words, hallucinations, abnormal dreams, libido increased, panic attacks, apathy, cognitive disorder, hypoaesthesia, nystagmus, dysarthria, myoclonus, decreased reflexes, dyskinesia, postural dizziness, psychomotor hyperactivity, amnesia, hyperaesthesia, burning sensation, loss of taste, intention tremor, stupor, syncope, visual disturbances, dry eyes, puffy eyes, visual field defect, decreased visual acuity, eye pain, weak, increased lacrimation, hyperacusis, tachycardia, atrioventricular block first degree, facial flushing, skin redness and warm feeling, hypotension, hypertension, dyspnea, dry nose, bloated abdomen, increased salivation, gastroesophageal reflux disease, oral hypoaesthesia, sweating, papular rash, muscle spasms, joint swelling, muscle cramps, myalgia, arthralgia, back pain, pain in the extremities, rigidity the muscles, dysuria, urinary incontinence, delayed ejaculation, sexual dysfunction, asthenia, fall, thirst, feeling of tightness in the chest, pain, malaise, chills, elevated creatine phosphokinase, alanine aminotransferase, and aspartate aminotransferase, decreased platelet count

Rare adverse reactions (> 1 / 10000)
Neutropenia, disinhibition, elevated mood, hypokinesia, parosmia, writing disorders, photopsia, eye irritation, mydriasis, abnormal spatial vision, "tunnel vision", oscillopsia, strabismus, photophobia, tachycardia, sinus arrhythmia, sinus bradycardia, cold extremities, cough, nasal congestion, epistaxis, rhinitis , snoring, throat tightness, ascites, pancreatitis, dysphagia, cold sweat, urticaria, neck pain, rhabdomyolysis, cervical spasm, renal failure, oliguria, amenorrhea, breast pain, discharge from the breast, dysmenorrhea, breast enlargement, generalized edema, fever, hyperglycemia, hypokalemia , increased creatinine, weight loss, lowered white blood cell count