Drug class lyrica
Antiepileptic
GABA analogue
Finished preparations
Lyrica ® also Pregabalin
Effect
Lyrica is an anticonvulsant, analgesic and anxiolytic-acting gamma-aminobutyric acid analogue. It binds to voltage-dependent calcium channels, so that the channels closed, thus reducing the calcium influx at the nerve endings and the release of excitatory neurotransmitters such as glutamate, noradrenaline and substance P is decreased.
Mechanism of action
Pegabalin is a gamma-aminobutyric acid analogue with the chemical name (S) -3 - (aminomethyl)-5-methylhexanoic. It binds to a subunit of auxilia (alpha2-delta protein) of spannungsabhängigien calcium channels in the CNS and potently displaced [3H]-gabapentin. By binding the channels are closed, thus reducing the calcium influx at the nerve endings and decreases the release of excitatory neurotransmitters such as glutamate, substance P and norepinephrine. lyrica does not bind to GABA receptors and therefore has no GABAergic activity.
Contraindications (counter indications)
The following are absolute counter indications (situations in which the drug should be administered in any case) and relative contraindications (situations in which the drug should be administered with caution) listed. For more information or answers to your questions please use the forum or ask your doctor or pharmacist.
Absolute contraindications
- Hypersensitivity to lyrica
- Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption
Relative contraindications
- Severe heart failure
- Pregnancy
- Breast-feeding
Side effects (adverse reactions)
